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Events
Mass Spectrometry Applications to the Clinical Lab 2012
December 16th 2011
POSTER at MSACL
Come and meet Mr. Jean Lacoursière and Dr. Pierre Picard in the AB Sciex Booth #6 during this event.
Phytronix Technologies Inc. will present 1 poster on Monday January 16th 2012 at 2:00 PM in the Exhibit Hall.
Selectivity Enhancement in High Throughput Analysis of Testosterone using Differential Ion Mobility Coupled to LDTD MS/MS
Self-Assigned Topic: New Advances
Pierre Picard
Phytronix Technologies inc
The Laser Diode Thermal DesorptionTM (LDTD) ionization source has been coupled to a mass spectrometer equipped with the SelexIONTM differential ion mobility cell, enabling a high throughput capacity for the analysis of testosterone in biological matrix, with sample-to-sample analysis time of 7 seconds. Sample preparation consisted of a liquid-liquid extraction of plasma with ethyl acetate. The lower limit of quantitation for the LDTD analysis of testosterone was limited by the blank interference from the presence of isobaric analytes, however the use of the orthogonal differential mobility spectrometry device allowed separation of those interferences, yielding an LOQ of 0.1 ng/ml testosterone.